Disentangling Multiple Sclerosis and Depression for Better Care

By | June 17, 2014

Due to the overlap of symptoms in clinical depression and multiple sclerosis, clinicians and researchers can be misled when caring for patients with MS who report fatigue and functional or cognitive impairment. Seeking to disentangle these complex relationships to improve care, Center faculty Douglas Gunzler, PhD, Adam Perzynski, PhD, Steven Lewis, MS, MBA, along with others at Case Western Reserve University and the Cleveland Clinic Mellen Center for Multiple Sclerosis, recently studied 3,507 patients with MS who also completed a self-reported depression screening tool (PHQ-9). Using a sophisticated causal modeling approach, the team found that overlap in symptoms was especially large for symptoms of fatigue. The team is developing an adjusted PHQ-9 screening tool for MS patients, as reported in the June 2014 issue of the Journal of Behavioral Medicine. Dr. Gunzler is a KL2 Scholar in the Cleveland CTSCĂ•s Multidisciplinary Clinical Research Training Program.Journal of Behavioral Medicine, Douglas Gunzler, PhD,Adam Perzynski, PhD