Ashwini Sehgal, MD, and Douglas Gunzler, PhD, were awarded a $3.3 million NIH R01 grant to study depression among patients receiving kidney dialysis. Many dialysis patients have depression that is difficult to diagnose and treat due in part to the overlap between depressive symptoms (e.g. appetite change, trouble sleeping, feeling tired) and symptoms related to kidney dialysis treatment (e.g. nausea, nocturnal cramps, feeling washed out after treatment). The goal of this project is to develop a screening instrument to improve diagnosis and to test the value of weekly directly observed antidepressant treatment in managing depression. Innovative features of the proposed project include the use of advanced statistical techniques to address overlap, administration of a long-acting weekly antidepressant, directly observed treatment, and a rigorous randomized controlled trial design. Dr. Sehgal is the Duncan Neuhauser Professor of Community Health Improvement and Professor of Medicine, Bioethics and Population and Quantitative Health Services. Dr. Gunzler is Assistant Professor of Medicine and Population and Quantitative Health Sciences.
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