Digoxin and reduction in mortality and hospitalization in heart failure: a comprehensive post hoc analysis of the DIG trial

By | January 4, 2006

In the European Heart Journal, Dr. Ali Ahmed and colleagues (including Thomas E. Love, Ph.D., of the Center for Health Care Research and Policy) studied the effectiveness of digoxin for heart failure. The study included a comprehensive re-analysis of data from the Digitalis Investigators Group trial sponsored in the early 1990s by the National Heart, Lung and Blood Institute. In the new article, the investigators found that administering low doses of digoxin to heart failure patients both improved their chances of survival and reduced their average number of future hospitalizations for heart failure. The results suggest that digoxin should play an important role in treating heart failure patients who continue to have symptoms despite the use of more expensive drugs such as ACE inhibitors or beta-blockers. (posted 1/2006)European Heart Journal,